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Filtered Search Results
Medchemexpress LLC SAR407899 (hydrochloride) | 923262-96-8 | 99.1% | 280.75 | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor. It has an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. It inhibits ROCK-2 more effectively than ROCK-1. This product exhibits potent vasorelaxant activity in various isolated arteries and dose-dependently lowers blood pressure in hypertensive SHRs. It also increases penile length in healthy and diabetic rabbits.
- Selective and potent ROCK inhibitor
- ATP-competitive mechanism of action
- Inhibits MYPTT696 phosphorylation
- Blocks thrombin-induced effects
- Inhibits cell proliferation and migration
- Potent vasorelaxant activity
- Reduces blood pressure
- Increases penile length
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Clemizole hydrochloride | 1163-36-6 | 99.99% | 362.30 | 1 ML
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Clemizole hydrochloride is an H1 histamine receptor antagonist that substantially inhibits HCV replication. It also acts as an inhibitor of the TRPC5 channel. The IC50 for RNA binding by NS4B is 24 nM, and its EC50 for viral replication is 8 μM.
- Inhibits HCV RNA replication
- Suppresses NS4B's RNA binding with low host cell toxicity
- Blocks TRPC5 currents and Ca2+ entry
- Exhibits selectivity for TRPC5 over TRPC4β, TRPC3, and TRPC6
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Imidapril hydrochloride | 89396-94-1 | 99.91% | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It suppresses the conversion of angiotensin I to angiotensin II, which reduces total peripheral resistance and systemic blood pressure. It can be used for research on hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE and MMP-9 inhibitor
- Suppresses the conversion of angiotensin I to angiotensin II
- Reduces total peripheral resistance and systemic blood pressure
- Applicable for research in hypertension, type 1 diabetic nephropathy, and chronic heart failure
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Ravidasvir hydrochloride | 1303533-81-4 | MFCD32705191 | 99.9% | 835.82 | C42H52Cl2N8O6 | 50MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Ravidasvir hydrochloride is the hydrochloride salt of ravidasvir, a pan-genotypic hepatitis C virus (HCV) NS5A inhibitor supplied as a high-purity research compound in solid form. It inhibits HCV replication at low nanomolar concentrations and is provided for laboratory research applications.
- High purity (99.9%).
- White to off-white solid physical form.
- Molecular weight 835.82 g/mol.
- Packaged as 50 MG for research use.
- Storage: sealed at 4°C; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month).
- Provides potent pan-genotypic NS5A inhibition with low nanomolar activity.
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![Medchemexpress LLC 3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)propan-1-one;hydrochloride | 16777-42-7 | 99.9% | 349.85 g·mol⁻¹ | C19H24ClNO3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000243265.png-250.jpg)
Medchemexpress LLC 3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-(3-methoxyphenyl)propan-1-one;hydrochloride | 16777-42-7 | 99.9% | 349.85 g·mol⁻¹ | C19H24ClNO3 | 5 MG
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Oxyfedrine hydrochloride is a vasodilator and an orally active β-adrenoreceptor agonist used in cardiovascular research. It decreases the tonicity of coronary vessels and has documented in vitro and in vivo effects on aldehyde dehydrogenase activity, myogenic activity, and blood viscosity.
- High purity (99.92%) suitable for research applications.
- Orally active β-adrenoreceptor agonist with vasodilatory activity.
- Molecular formula C19H24ClNO3; molecular weight 349.85 g·mol⁻¹.
- Solid, white to off-white appearance for easy handling.
- Soluble in DMSO (175 mg/mL); ultrasonic and newly opened DMSO recommended.
- Certificate of analysis available to support quality control.
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Medchemexpress LLC Caroverine hydrochloride | 55750-05-5 | 98.9% | 401.93 g/mol | C22H28ClN3O2 | 500 MG
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Caroverine hydrochloride is the hydrochloride salt of caroverine, a nonselective NMDA and AMPA glutamate receptor antagonist supplied for laboratory research use. It is provided as a dry powder for preparation of solution stocks and for in vitro or in vivo pharmacology studies.
- CAS number 55750-05-5.
- Molecular weight 401.93 g/mol.
- Chemical formula C22H28ClN3O2.
- Form white to off-white powder.
- Purity 98.9% (HPLC).
- Soluble in DMSO and water for stock preparation.
- Storage store sealed at 4°C, protect from moisture.
- Research use for NMDA/AMPA receptor pharmacology.
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Medchemexpress LLC Aprindine hydrochloride | 33237-74-0 | 99.0% | C22H31ClN2 | 50 MG
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Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. It primarily blocks sodium channels (INa) and significantly inhibits delayed potassium currents, helping to prolong the atrial effective refractory period (AERP) and prevent atrial fibrillation. It also regulates intracellular calcium ion concentration by inhibiting the Na+/Ca2+ exchange current (INCX), further stabilizing cardiac electrical activity. It is used in the study of atrial fibrillation (AF) and ventricular arrhythmias.
- Functions as an Ib-class anti-arrhythmic agent.
- Blocks sodium channels (INa) and inhibits delayed potassium currents.
- Regulates intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX).
- Used for studying atrial fibrillation (AF) and ventricular arrhythmias.
- Inhibits proliferation of bone marrow cells and human lymphocytes.
- Demonstrates anti-arrhythmic effects in vivo.
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Medchemexpress LLC Ansofaxine hydrochloride | 916918-84-8 | 417.97 | 25 MG
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Ansofaxine hydrochloride is a triple reuptake inhibitor designed to inhibit serotonin, dopamine, and norepinephrine reuptake. It demonstrates IC50 values of 723 nM, 491 nM, and 763 nM for these reuptake processes, respectively. This compound is intended for research use only.
- Triple reuptake inhibitor
- Inhibits serotonin, dopamine, and norepinephrine reuptake
- Intended for research use only
- Appears as a solid
- Color ranges from white to off-white
- Recommended storage for solid is 4°C, sealed and away from moisture
- For solutions, store at -80°C for up to 6 months, or -20°C for 1 month
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Medchemexpress LLC Embramine hydrochloride | 13977-28-1 | 384.74 | 5 MG
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Embramine hydrochloride is a monoethanolamine compound that functions as an antihistamine and anticholinergic. It is intended for research use only.
- Functions as an antihistamine
- Functions as an anticholinergic
- Monoethanolamine compound
- For research use only
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Medchemexpress LLC PRT062607 Hydrochloride | 1370261-97-4 | C19H24ClN9O | 100 MG
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PRT062607 (P505-15) Hydrochloride is an orally available Syk inhibitor (IC50: 1 nM) that inhibits inflammation and induces apoptosis. It also demonstrates potent antitumor activity in tumor xenograft mouse models.
- Inhibits phosphorylation of ERK(Y204), AKT(S473), and SYK(Y352) in Ramos cells.
- Inhibits BLNK Tyr84 phosphorylation.
- Inhibits B cell antigen receptor-mediated B cell signaling and activation in human whole blood.
- Inhibits Fc receptor 1-mediated induced basophil degranulation.
- Demonstrates significant activity against various kinases including Fgr, MLK1, Yes, Flt3, PAK5, Lyn, cSRC, Lck, Pyk, and FAK.
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Medchemexpress LLC Yonkenafil hydrochloride | 804519-64-0 | 99.4% | 524.08 | C24H34ClN5O4S | 10MG
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Yonkenafil hydrochloride is a research-grade phosphodiesterase 5 (PDE5) inhibitor supplied as the hydrochloride salt for biochemical and pharmacological studies. It is commonly used in in vitro and in vivo experiments to investigate PDE5-mediated signaling, vascular effects, and neuroprotection, and is typically handled as a DMSO-soluble compound.
- Research-grade PDE5 inhibitor for biochemical and pharmacological studies.
- High purity suitable for sensitive assays.
- Hydrochloride salt form improves solubility in polar solvents.
- Soluble in DMSO for easy assay preparation.
- Reported molecular formula C24H34ClN5O4S and molecular weight 524.08.
- Available in multiple small pack sizes for laboratory use.
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Medchemexpress LLC LY3020371 hydrochloride | 1377615-44-5 | 99.2% | 395.81 | 5 MG
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LY3020371 hydrochloride is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. It exerts an antidepressant-like signature in vivo.
- Potent, selective mGlu2/3 receptor antagonist.
- Ki values of 5.3 nM for mGluR2 and 2.5 nM for mGluR3.
- Blocks cAMP formation with an IC50 of 16.2 nM.
- Exerts an antidepressant-like signature in vivo.
- Blocks agonist-suppressed Ca2+ oscillations (IC50=34 nM) and in hippocampal slices (IC50=46 nM).
- Intravenous injection leads to effective mGlu2/3 receptor blockade in rat cerebrospinal fluid.
- Promotes wakefulness, reducing NREM sleep in Wistar rats.
- Available in various sizes and forms.
- High purity (99.18%).
- Detailed documentation provided.
- Solubility and dissolution protocols available.
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Medchemexpress LLC Nevanimibe hydrochloride | 133825-81-7 | 99.5% | 458.08 | 5 MG
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Nevanimibe hydrochloride is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. It also inhibits ACAT2 with an EC50 of 368 nM. This compound induces cell apoptosis and has the potential for adrenocortical cancer, making it suitable for relevant research.
- Orally active and selective ACAT1 inhibitor (EC50 of 9 nM)
- Inhibits ACAT2 (EC50 of 368 nM)
- Induces cell apoptosis
- Has potential for adrenocortical cancer research
- Solid appearance, white to off-white color
- Stable under recommended storage conditions
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Medchemexpress LLC Emixustat hydrochloride (ACU-4429 hydrochloride) | 1141934-97-5 | 99.3% | 299.84 | 1 ML
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Emixustat hydrochloride (ACU-4429 hydrochloride) is an orally active RPE65 inhibitor. It functions as a visual cycle modulator, regulating visual cycle activity by inhibiting retinol isomerization, and shows potential for studying vision disorders, including age-related macular degeneration (AMD).
- Orally active RPE65 inhibitor
- Functions as a visual cycle modulator
- Regulates visual cycle activity by inhibiting retinol isomerization
- Potential for studying vision disorders such as age-related macular degeneration (AMD)
- Inhibits RPE65 activity with an IC50 of 4.4 nM
- Reduces 11-cis-retinol production
- Shown to inhibit neovascularization and protect the retina in an oxygen-induced retinopathy mouse model
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Medchemexpress LLC VU0357017 hydrochloride | 1135242-13-5 | 98.63% | 369.89 | 1 ML
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VU0357017 hydrochloride is a potent, selective, and brain-penetrant allosteric agonist of the M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. It is highly selective for M1, showing no activity at M2-M5 receptors up to 30 μM. This compound is used in research for conditions such as Alzheimer's disease and schizophrenia.
- Potent and selective M1 muscarinic acetylcholine receptor agonist.
- Exhibits brain penetrant properties.
- Highly selective for M1 over M2-M5 receptors.
- Used for the research of Alzheimer's disease and schizophrenia.
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